2023

Senay O, Seethaler M, Makris N, Yeterian E, Rushmore J, Cho KIK, Rizzoni E, Heller C, Pasternak O, Szczepankiewicz F, Westin CF, Losak J, Ustohal L, Tomandl J, Vojtisek L, Kudlicka P, Kikinis Z, Holt D, Lewandowski KE, Lizano P, Keshavan MS, Öngür D, Kasparek T, Breier A, Shenton ME, Seitz-Holland J, Kubicki M. A preliminary choroid plexus volumetric study in individuals with psychosis. Hum Brain Mapp. 2023 Apr 15. doi: 10.1002/hbm.26224.

Zhang L, Lizano P, Xu Y, Rubin LH, Lee AM, Lencer R, Reilly JL, Keefe RSE, Keedy SK, Pearlson GD, Clementz BA, Keshavan MS, Gershon ES, Tamminga CA, Sweeney JA, Hill SK, Bishop JR. Peripheral inflammation is associated with impairments of inhibitory behavioral control and visual sensorimotor function in psychotic disorders. Schizophr Res. 2023 May 23. doi: 10.1016/j.schres.2023.03.030.

2022

Li CY, Garg I, Bannai D, Kasetty M, Katz R, Adhan I, Douglas KA, Wang J, Kim L, Keshavan M, Lizano P, Miller JB. Sex-Specific Changes in Choroid Vasculature Among Patients with Schizophrenia and Bipolar Disorder. Clinical ophthalmology (Auckland, N.Z.) 2022 July. doi: 10.2147/OPTH.S352731

Zeng R, Garg I, Bannai D, Kasetty M, Katz R, Park JY, Lizano P, Miller JB. Retinal microvasculature and vasoreactivity changes in hypertension using optical coherence tomography-angiography. Graefes Arch Clin Exp Ophthalmol. 2022 Jun 9. doi: 10.1007/s00417-022-05706-6.

Bitanihirwe BKY, Lizano P, Woo TW. Deconstructing the functional neuroanatomy of the choroid plexus: an ontogenetic perspective for studying neurodevelopmental and neuropsychiatric disorders. Mol Psychiatry. 2022 May 26:1–10. doi: 10.1038/s41380-022-01623-6.

Raymond N, Reinhart RMG, Keshavan M, Lizano P. An Integrated Neuroimaging Approach to Inform Transcranial Electrical Stimulation Targeting in Visual Hallucinations. Harv Rev Psychiatry. 2022 May-Jun 01;30(3):181-190. doi: 10.1097/HRP.0000000000000336.

Türközer HB, Lizano P, Adhan I, Ivleva EI, Lutz O, Zeng V, Zeng A, Raymond N, Bannai D, Lee A, Bishop JR, Clementz BA, Pearlson GD, Sweeney JA, Gershon ES, Keshavan MS, Tamminga CA. Regional and Sex-Specific Alterations in the Visual Cortex of Individuals With Psychosis Spectrum Disorders. Biol Psychiatry. 2022 Apr 12:S0006-3223(22)01159-3. doi: 10.1016/j.biopsych.2022.03.023

Zhang L, Lizano P, Guo B, Xu Y, Rubin LH, Hill SK, Alliey-Rodriguez N, Lee AM, Wu B, Keedy SK, Tamminga CA, Pearlson GD, Clementz BA, Keshavan MS, Gershon ES, Sweeney JA, Bishop JR. Inflammation subtypes in psychosis and their relationships with genetic risk for psychiatric and cardiometabolic disorders. Brain Behav Immun Health. 2022 Apr 8;22:100459. doi: 10.1016/j.bbih.2022.100459.

Zhang L, Hill SK, Guo B… Lizano P, Ivleva EI, Reilly JL, Keefe RSE, Keedy SK, Tamminga CA, Pearlson GD, Clementz BA, Keshavan MS, Gershon ES, Sweeney JA, Bishop JR. Impact of polygenic risk for coronary artery disease and cardiovascular medication burden on cognitive impairment in psychotic disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Mar 8;113:110464. doi: 10.1016/j.pnpbp.2021.110464.

Ward HB, Brady RO, Halko MA, Lizano P. Noninvasive Brain Stimulation for Nicotine Dependence in Schizophrenia: A Mini Review. Front Psychiatry. 2022 Feb 9;13:824878. doi: 10.3389/fpsyt.2022.824878.

Hoang D, Xu Y, Lutz O, Bannai D, Zeng V, Bishop JR, Keshavan M, Lizano P. Inflammatory Subtypes in Antipsychotic-Naïve First-Episode Schizophrenia are Associated with Altered Brain Morphology and Topological Organization. Brain Behav Immun. 2022 Feb;100:297-308. doi: 10.1016/j.bbi.2021.11.019.

Bishop JR, Zhang L, Lizano P. Inflammation Subtypes and Translating Inflammation-Related Genetic Findings in Schizophrenia and Related Psychoses: A Perspective on Pathways for Treatment Stratification and Novel Therapies. Harv Rev Psychiatry. 2022 Jan-Feb 01;30(1):59-70. doi: 10.1097/HRP.0000000000000321.

Lai M, Hegde R, Kelly S, Bannai D, Lizano P, Stickgold R, Manoach DS, Keshavan M. Investigating sleep spindle density and schizophrenia: A meta-analysis. Psychiatry Research. 2022 Jan;307:114265. doi: 10.1016/j.psychres.2021.114265.

2021

Johnson MC, Baum ML, Lizano P. Falling through the cracks: Missed opportunities for diagnosing and treating lupus in schizophrenia. Schizophrenia Research. 2021 Dec;238:185-187. doi: 10.1016/j.schres.2021.10.013.

Deepthi Bannai, Iniya Adhan… John B Miller, Paulo Lizano.Quantifying Retinal Microvascular Morphology in Schizophrenia Using Swept-Source Optical Coherence Tomography Angiography, Schizophrenia Bulletin, 2021;, sbab111, https://doi.org/10.1093/schbul/sbab111.

Grover S, Keshavan MS, Lizano PL, Reinhart RMG. Proximate markers of cognitive dysfunction in schizophrenia. Schizophrenia Research. 2021 Jul 26:S0920-9964(21)00272-3. doi: 10.1016/j.schres.2021.07.019.

Gandu S, Bannai D, Kasetty M, …, Miller J, Keshavan M, Lizano P. Inter-Device Reliability of Swept Source and Spectral Domain Optical Coherence Tomography Retinal Structure Measurements in Schizophrenia.Biological Psychiatry, vol. 89, no. 9, 2021, doi:10.1016/j.biopsych.2021.02.687.

del Re E, Zeng V, Alliey-Rodriguez N, Lizano P, Bolo N, Lutz O, Pearlson G, Sweeney J, Clementz B, Gershon E, Tamminga C, Keshavan M. Anterior-posterior axis of hippocampal subfields across psychoses: A B-SNIP study. Biomarkers in Neuropsychiatry, vol. 5, 2021, https://doi.org/10.1016/j.bionps.2021.100037

Hoang D, Lizano P, Lutz O, Zeng V, Raymond N, Miewald J, Montrose D, Keshavan M. Thalamic, Amygdalar, and hippocampal nuclei morphology and their trajectories in first episode psychosis: A preliminary longitudinal study. Psychiatry Res Neuroimaging. 2021 Jan 8;309:111249. doi: 10.1016/j.pscychresns.2021.111249. Epub ahead of print. PMID: 33484937.

Kelly S, Guimond S, Pasternak O, Lutz O, Lizano P,.., Keshavan MS. White matter microstructure across brain-based biotypes for psychosis - findings from the bipolar-schizophrenia network for intermediate phenotypes. Psychiatry Res Neuroimaging. 2021 Dec 16;308:111234. doi: 10.1016/j.pscychresns.2020.111234. Epub ahead of print. PMID: 33385763.

2020

Pong S, Lizano P, Karmacharya R. Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells. J Vis Exp. 2020 Nov 19;(165). doi: 10.3791/61629. PMID: 33283783.

Lizano P, Lutz O, Xu Y, .., Keshavan MS, Sweeney JA, Bishop JR. Multivariate relationships between peripheral inflammatory marker subtypes and cognitive and brain structural measures in psychosis. Mol Psychiatry. 2020 Oct. doi: 10.1038/s41380-020-00914-0.

Tamminga CA., Clementz BA., Pearlson G., Lizano P., et al (2020). Biotyping in psychosis: using multiple computational approaches with one dataset. Neuropsychopharmacology. 2020 Sep. doi:10.1038/s41386-020-00862-x

Pong S., Karmacharya R.,Sofman M.,Bishop R. J., Lizano P. (2020). The Role of Brain Microvascular Endothelial Cell and Blood-Brain Barrier Dysfunction in Schizophrenia. Complex Psychiatry. doi.org/10.1159/000511552.

Bannai, D., Lutz, O., & Lizano, P. (2020). Neuroimaging considerations when investigating choroid plexus morphology in idiopathic psychosis. Schizophrenia Research. 2020 July. doi:10.1016/j.schres.2020.07.013

Zeng, V., Lizano, P., Bolo, N. R., Lutz, O., Brady, R., Ivleva, E. I., . . . & Keshavan, M. (2020). Altered cerebral perfusion in bipolar disorder: A pCASL MRI study. 2020 June. Bipolar Disorders. doi:10.1111/bdi.12966

Lutz, O., Lizano, P., Mothi, S. S., Zeng, V., Hegde, R. R., Hoang, D. T., . . . & Keshavan, M. S. (2020). Do neurobiological differences exist between paranoid and non-paranoid schizophrenia? Findings from the bipolar schizophrenia network on intermediate phenotypes study. Schizophrenia Research. 2020 June. doi:10.1016/j.schres.2020.02.011

Adhan, I., Lizano, P., Bannai, D., Lutz, O., Dhaliwal, K., Zeng, V., . . . & Keshavan, M. (2020). Visual Cortical Alterations and their Association with Negative Symptoms in Antipsychotic-Naïve First Episode Psychosis. Psychiatry Research, 288, 112957. 2020 June. doi:10.1016/j.psychres.2020.112957

Bannai, D., & Lizano, P. (2020). Identifying retinal layer endophenotypes for schizophrenia. Schizophrenia Research, 220, 25-26. 2020 June. doi:10.1016/j.schres.2020.03.055

Bannai D., Lizano P., Kasetty M., … Miller JB., Keshavan M. Retinal layer abnormalities and their association with clinical and brain measures in psychotic disorders: A preliminary study. Psychiatry Res Neuroimaging, 299:111061. Epub 2020 Feb, 2020 May 30. doi: 10.1016/j.pscychresns.2020.111061. 

Keshavan M., Lizano P., Prasad K (2020). The synaptic pruning hypothesis of schizophrenia: promises and challenges. World Psychiatry, 19(1). 2020 Feb doi: 10.1002/wps.20725.

Keshavan MS., Collin G., Guimond S., Kelly S., Prasad KM., Lizano P (2020). Neuroimaging in Schizophrenia. Neuroimaging Clin N Am, 30(1):73-83. 2020 Feb. doi: 10.1016/j.nic.2019.09.007.

Lizano P., Bannai D., Lutz O., Kim LA., Miller J., Keshavan M (2020). A Meta-analysis of Retinal Cytoarchitectural Abnormalities in Schizophrenia and Bipolar Disorder. Schizophr Bull, 4;46(1):43-53. doi: 10.1093/schbul/sbz029.

2019

Adhan, I., Bannai, D., & Lizano, P. (2020). Commentary: Can retinal imaging biomarkers inform psychosis pathophysiology? Schizophrenia Research, 215, 3-5. doi:10.1016/j.schres.2019.10.020

Lizano, P., Dhaliwal, K., Lutz, O., Mothi, S. S., Miewald, J., Montrose, D., & Keshavan, M. (2019). Trajectory of neurological examination abnormalities in antipsychotic-naïve first-episode psychosis population: A 1 year follow-up study. Psychological Medicine, 1-9. doi:10.1017/s0033291719002162

Lizano, P., Lutz, O., Ling, G., Lee, A. M., Eum, S., Bishop, J. R., . . . & Keshavan, M. (2019). Association of Choroid Plexus Enlargement With Cognitive, Inflammatory, and Structural Phenotypes Across the Psychosis Spectrum. American Journal of Psychiatry, 176(7), 564-572. doi:10.1176/appi.ajp.2019.18070825

Keshavan, M., Lizano, P., & Padmanabhan, J. (2019). Brain changes in the early course of schizophrenia.

Lutz, O., Lizano, P., Mothi, S. S., Joseph, A., Tandon, N., Ormston, L., . . . & Shashi, V. (2019). Hypogyrification and its association with cognitive impairment in children with 22q11.2 deletion Syndrome: A preliminary report. Psychiatry Research: Neuroimaging, 285, 47-50. doi:10.1016/j.pscychresns.2019.01.007

Lizano, P., Prasad, K. M., & Keshavan, M. S. (2019). Commentary: Do Complement factors "connect the dots" in schizophrenia?. Schizophrenia Research, 204, 4–6. https://doi.org/10.1016/j.schres.2018.12.042

Burke, M. J., Lizano, P., Jacobs, C., & Stern, T. A. (2020). Post-traumatic Stress Disorder Symptom Substitution as a Cause of Functional Neurological Disorder. Psychosomatics, 61(1), 81-85. doi:10.1016/j.psym.2019.03.003

2018

Lizano, P., Lutz, O., Ling, G., Padmanabhan, J., Tandon, N., Sweeney, J., . . . & Keshavan, M. (2018). VEGFA GENE variation influences hallucinations and frontotemporal morphology in psychotic disorders: A B-SNIP study. Translational Psychiatry, 8(1). doi:10.1038/s41398-018-0271-y

2017

Hill, K., Bolo, N., Mothi, S. S., Lizano, P., Guimond, S., Tandon, N., . . . & Keshavan, M. (2017). Subcortical surface shape in youth at familial high risk for schizophrenia. Psychiatry Research: Neuroimaging, 267, 36-44. doi:10.1016/j.pscychresns.2017.07.002

Lizano, P., Rashed, E., Stoll, S., Zhou, N., Wen, H., Hays, T. T., . . . Qiu, H. (2017). The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo. Scientific Reports, 7(1). doi:10.1038/srep46324

Lizano PL., Yao JK., Tandon N., Mothi SS., Montrose DM., Keshavan MS (2017). Association of sFlt-1 and worsening psychopathology in relatives at high risk for psychosis: A longitudinal study. Schizophr Res, 183:75-81. doi: 10.1016/j.schres.2016.11.015.

2016

2011 - 2015

Lizano PL., Keshavan MS., Tandon N., Mathew IT., Mothi SS., Montrose DM., Yao JK (2016). Angiogenic and immune signatures in plasma of young relatives at familial high-risk for psychosis and first-episode patients: A preliminary study. Schizophr Res, 170(1):115-22. doi: 10.1016/j.schres.2015.12.001.

Rashed, E., Lizano, P., Dai, H., Thomas, A., Suzuki, C. K., Depre, C., & Qiu, H. (2015). Heat Shock Protein 22 (Hsp22) Regulates Oxidative Phosphorylation upon Its Mitochondrial Translocation with the Inducible Nitric Oxide Synthase in Mammalian Heart. Plos One, 10(3). doi:10.1371/journal.pone.0119537

Haller, C. S., Padmanabhan, J. L., Lizano, P., Torous, J., & Keshavan, M. (2014). Recent advances in understanding schizophrenia. F1000Prime Reports, 6. doi:10.12703/p6-57

Lizano, P., Rashed, E., Kang, H., Dai, H., Sui, X., Yan, L., . . . & Depre, C. (2013). The valosin-containing protein promotes cardiac survival through the inducible isoform of nitric oxide synthase. Cardiovascular Research, 99(4), 685-693. doi:10.1093/cvr/cvt136

Laure, L., Long, R., Lizano, P., Zini, R., Berdeaux, A., Depre, C., & Morin, D. (2012). Cardiac H11 kinase/Hsp22 stimulates oxidative phosphorylation and modulates mitochondrial reactive oxygen species production: Involvement of a nitric oxide-dependent mechanism. Free Radical Biology and Medicine, 52(11-12), 2168-2176. doi:10.1016/j.freeradbiomed.2012.03.001

Qiu, H., Lizano, P., Laure, L., Sui, X., Rashed, E., Park, J. Y., Hong, C., Gao, S., Holle, E., Morin, D., Dhar, S.K., Wager, T., Berdeaux, A., Tian, B., Vatner, S.F., & Depre, C. (2011). H11 Kinase/Heat Shock Protein 22 Deletion Impairs Both Nuclear and Mitochondrial Functions of STAT3 and Accelerates the Transition Into Heart Failure on Cardiac Overload. Circulation, 124(4), 406-415. doi:10.1161/circulationaha.110.013847

Chen, L., Lizano, P., Zhao, X., Sui, X., Dhar, S. K., Shen, Y., Vatner, S.F., & Depre, C. (2011). Preemptive conditioning of the swine heart by H11 kinase/Hsp22 provides cardiac protection through inducible nitric oxide synthase. American Journal of Physiology-Heart and Circulatory Physiology, 300(4). doi:10.1152/ajpheart.00979.2010

2007-2010

Hedhli, N., Lizano, P., Hong, C., Fritzky, L. F., Dhar, S. K., Liu, H., Tian, Y., Gao, S., Madura, K., Vatner, S.F., & Depre, C. (2008). Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload. American Journal of Physiology-Heart and Circulatory Physiology, 295(4). doi:10.1152/ajpheart.00532.2008

Garay, E., Jankowski, P., Lizano, P., Marczak, S., Maehr, H., Adorini, L., Uskokovic, M.R., & Studzinski, G. P. (2007). Calcitriol derivatives with two different side-chains at C-20. Part 4: Further chain modifications that alter VDR-dependent monocytic differentiation potency in human leukemia cells. Bioorganic & Medicinal Chemistry, 15(13), 4444-4455. doi:10.1016/j.bmc.2007.04.034

Abstracts and Posters

Lizano, P., Bannai, D., Adhan, I., Douglas, K.A.A., Kasetty, M., Keshavan, M., & Miller, J.B. Superficial Retinal Vascular Abnormalities in Schizophrenia as Shown by Swept Source OCT-Angiography: A Preliminary Study. Biological Psychiatry, 87(9), S445.

Hegde, R., Kelly, S., Lizano, P., Lutz, O., Karayumak, S.C., Pasternak, O., Kubicki, M., Eack, S., & Keshavan, M. Effects of Cognitive Enhancement Therapy on White Matter Microstructure and Extracellular Free-Water. Biological Psychiatry, 87(9), S279.

Bannai, D., Adhan, I., Douglas, K.A.A., Kasetty, M., Lutz, O., Keshavan, M. Miller, J., & Lizano, P. Shedding Light on Pathophysiologic Mechanisms in Schizophrenia and Bipolar Disorder Through Analysis of Retinal Structural-Vascular-Functional Relationships. Biological Psychiatry, 87(9), S338-S339.

Zeng, V., Lizano, P., Hegde, R., Lutz, O., Hoang, D., Adhan, I., … & Keshvan, M. Thalamic Nuclei Reductions Across the Psychosis Spectrum: A BSNIP Study. Biological Psychiatry, 87(9), S343-S344.

Lai, M., Kelly, S., Hegde, R., Bannai, D., Lizano, P., & Keshavan, M. Investigating Sleep Spindle Density and Schizophrenia: A Meta-Analysis. Biological Psychiatry, 87(9), S299.

Adhan, I., Lizano, P., Bannai, D., Kasetty, M., Miller, J., & Keshavan, M. A Pilot Study of Retinal RNFL, GCL, and Choroidal Layer in Schizophrenia Using Swept Source Optical Tomography Coherence Imaging. Biological Psychiatry, 87(9), S243-S244.

Douglas, K.A.A., Bannai, D., Adhan, I., Kasetty, M., Miller, J.B., Keshavan, M., & Lizano, P. A Preliminary Study Using OCT-A to Determine Deep Layer Retinal Vascular Changes in Schizophrenia. Biological Psychiatry, 87(9), S244-S245.

Turkozer, H.B., Lizano, P., Adhan, I., Ivleva, E.I., Lutz, O., Zeng, A., Raymond, N., Clementz, B.A., Pearlson, G., Sweeney, J., Gershon, E., Keshavan, & Tamminga, C. Neuroanatomical Sex Differences in the Visual Cortex of Individuals With Psychosis: Findings From the Bipolar-Schizophrenia Network on Intermediate Phenotypes. Biological Psychiatry, 87(9), S205.

Pong, S., Lizano, P., & Karmacharya, R. Investigating Blood-Brain Barrier Dysfunction in Schizophrenia Using Brain Microvascular Endothelial Cells Derived From Patient-Specific Stem Cells. Biological Psychiatry, 87(9), S189-S190.

Lizano, P., Rashed, E., Depre, C., & Qiu, H. The Valosin-Containing Protein Provides a Novel Mechanism of Preconditioning in vivo. Circulation, 124(S21), A15528-A15528.

Lizano, P., Dai, H., Sui X., Depre, C. (2010). Activation of the Valosin-Containing Protein by H11 Kinase/Hsp22 Promotes Cardiac Cell Survival. Circulation, 122(S21), A12704-A12704.

Qiu, H., Lizano, P., Laure, L., Sui X., Hong, C., Morin, D., Tin, B., Berdeaux, A., Vatner, S., & Depre, C. (2010). Deletion of H11 Kinase/Hsp22 Prevents Stress-Induced Activation of STAT3 in the Heart. Circulation, 122 (S21), A12711-A12711.

Lizano, P., Dai, H., & Depre, C. (2010). H11 Kinase/Hsp22-mediated activation of the valosin-containing protein promotes the expression of the inducible isoform of nitric oxide synthase in the heart. Federation of American Societies to Experimental Biology, 24(S1), 816.2-816.2. doi:10.1096/fasebj.24.1_supplement.816.2

Laure L., Lizano, P., Zini, R., Morin, D., Depre, C., & Berdeaux, A. (2009). Cardiac-Specific Over-Expression of H11 Kinase/Hsp22 Regulates Mitochondrial Oxidative Phosphorylation by a Nitric Oxide-Dependent Mechanism Reproducing Ischemic Preconditioning. Circulation, 120(S8), S373-S373.