INFLAMMATION
Alterations in inflammatory markers, immunological pathways, blood brain barrier functioning, and microvasculature have been reported in psychosis and can be assessed using markers acquired from plasma samples. These markers, particularly peripheral cytokines, have been associated with inflammation, immune dysregulation, oxidative stress, and microvascular dysfunction as well as with cognitive, clinical, and neurophysiological impairments in psychosis. Given the neurobiological heterogeneity observed across the psychosis spectrum, peripheral cytokine levels may identify biologically-based psychosis subtypes and targeted interventions could be developed. Our lab investigate the choroid plexus, a structure located within the lateral, third and fourth ventricles. The choroid plexus secretes CSF along with neurotrophic, angiogenic and inflammatory factors that influence brain development and are implicated in psychosis, yet this structure has been ignored in clinical neuroscience. Using structural MRI, our group segmented choroid plexus volumes and observed enlargements in individuals with psychosis as well as their first-degree family members. To continue this work, our group has continued to develop choroid plexus segmentation algorithms for more accurate measurements. 
Image from Liddelow 2015