Treatment of Bipolar Mania with Transcranial Electric Stimulation
About:
Mania is a core symptom of bipolar disorder involving periods of euphoria, delusions and over activity, however most drug therapies for mania are intolerable and ineffective. Transcranial Electric stimulation (tES) is a safe, non-invasive, painless way to stimulate the brain and it has been found to decrease risk taking behavior when applied to the orbitofrontal cortex. Our study hopes to use EEG and other assessments to monitor the effects of specialized transcranial electric current stimulation on mania symptoms and ultimately pave the way for personalized treatments for individuals with Bipolar disorder.
This study is run through Beth Israel Deaconess Medical Center/ Harvard Medical School and includes compensation for participants.
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The purpose of this study is to determine whether transcranial electric stimulation targeted to the orbitofrontal cortex in individuals with mania can decrease symptoms of mania.
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Individuals with bipolar disorder or bipolar type schizoaffective disorder who are between the ages of 18 and 65 who are either experiencing mild symptoms of mania or have experienced symptoms of mania in the past.
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Participation in this study entails 5 consecutive days of twice-daily transcranial electric stimulation (tES), as well as baseline testing on the first day of stimulation, and follow-up visits both 1 month and 3 months after stimulation.
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o Questionnaires about your psychiatric, medical, and substance use history at the baseline visit
o Urine test to screen for substance use at the baseline visit
o Transcranial electric stimulation (for 5 consecutive days)
o EEG (Electroencephalogram) (for 5 consecutive days)
o Clinical and cognitive testing at baseline and at each follow-up visit
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Each visit will be held at Massachusetts Mental Health Center at Beth Israel Deaconess Medical Center.
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The compensation for this study is adjusted based on how many of the tasks are completed. Participants will be compensated after completing the five sessions of tES and then again after their one month follow up.
